HLA-net

HLA-net

HLA-net is an European network of the HLA diversity for histocompatibility, clinical transplantation, epidemiology and population genetics.

Guidelines on how to use the tool are provided with examples of input lines (e.g. for searching non-specific/multiple/complex phenotype(s)).

 

Allele Frequency Net Database

Allele Frequency Net Database

One of our partners Derek Middleton (Royal Liverpool Hospital) has set up and runs a website, that hosts the Allele Frequency Net Database (AFND).
The database is an online repository that contains information on the frequencies of immune genes and their corresponding alleles in different populations.

This database provides a central source, freely available to all, for the storage of allele frequencies from different polymorphic areas in the Human Genome. Users can contribute the results of their work into one common database and can perform database searches on information already available.

The Eurostam pheno search utility is available with updated graphical and numerical outputs.

 

Kick off meeting – Feb 2013

Kick off meeting – Feb 2013

On February 15, 2013 the EUROSTAM Kick Off meeting took place in the nice atmosphere of Kasteel Oud-Poelgeest in Oegstgeest close to Leiden in the Netherlands.

After an introduction by the coordinator of the project Prof. Frans Claas, all participants introduced themselves, their institute and their tasks within the EUROSTAM project.

The reason for starting up this project was the fact that only a proportion of the highly sensitized patients can be transplanted within the own organization. Patients with rare HLA phenotypes are waiting for a long time without any chance that they will receive a kidney from a crossmatch negative donor. Therefore, international collaboration between countries where the HLA phenotypes are different will enhance transplantation of this difficult transplant patient group.

The aim of the project is to perform simulation studies to check the beneficial effect of such collaboration and to perform a number of transplants in order to obtain an idea on the logistics of such an exercise. In addition, HLA has become very complicated. At the moment more than 5.000 different HLA class I alleles have been identified.

An additional aim of the project is to test whether it is possible to change from HLA allele typing to HLA epitope typing. It is to be expected that about 180 epitopes can explain the serological reactions against the more than 5.000 HLA alleles.

The third objective is to check whether the presence of donor specific endothelial cells antibodies, either complement fixing or not, has an impact on the outcome of transplants in highly sensitized patients.